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1

Discovery of Multifold Modified Sialosides as Human CD22/Siglec-2 Ligands with Nanomolar Activity on B-Cells

Prescher, Horst, Schweizer, Astrid, Kuhfeldt, Elena, Nitschke, Lars, Brossmer, Reinhard

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 840 KB

english, 2014

2

Induction of experimental autoimmune encephalomyelitis in transgenic mice expressing ovalbumin in oligodendrocytes

Yi Cao, Catherine Toben, Shin-Young Na, Kirsten Stark, Lars Nitschke, Alan Peterson, Ralf Gold, Anneliese Schimpl, Thomas Hünig

Journal:

European Journal of Immunology

Year:

2006

Language:

english

File:

PDF, 366 KB

english, 2006

3

Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy

Sivertsen Åsrud, Kathrine, Pedersen, Line, Aesoy, Reidun, Muwonge, Haruna, Aasebø, Elise, Nitschke Pettersen, Ina Katrine, Herfindal, Lars, Dobie, Ross, Jenkins, Stephen, Berge, Rolf Kristian, Henders

Journal:

Scientific Reports

Year:

2019

File:

PDF, 7.38 MB

2019

4

Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction

Özgör, Lamia, Meyer, Sarah J., Korn, Marina, Terörde, Klara, Nitschke, Lars

Journal:

The Journal of Immunology

Year:

2018

Language:

english

File:

PDF, 2.13 MB

english, 2018

5

Critical redundant functions of the adapters Grb2 and Gads in platelet (hem)ITAM signaling in mice

Vögtle, Timo, Baig, Ayesha A., Volz, Julia, Duchow, Timothy B., Pleines, Irina, Dütting, Sebastian, Nitschke, Lars, Watson, Stephen P., Nieswandt, Bernhard

Journal:

Year:

2020

Language:

english

File:

PDF, 2.05 MB

english, 2020

6

The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module

Engels, Niklas, König, Lars M., Schulze, Wiebke, Radtke, Daniel, Vanshylla, Kanika, Lutz, Johannes, Winkler, Thomas H., Nitschke, Lars, Wienands, Jürgen

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 2.11 MB

english, 2014

7

The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection

Fernandes, Vitor E., Ercoli, Giuseppe, BÃ©nard, Alan, Brandl, Carolin, Fahnenstiel, Hannah, MÃ¼ller-Winkler, Jennifer, Weber, Georg F., Denny, Paul, Nitschke, Lars, Andrew, Peter W., Philpott, Dana J.

Journal:

Year:

2020

File:

PDF, 3.80 MB

2020

8

Aminoglycoside suppression at UAG, UAA and UGA codons inEscherichia coliand human tissue culture cells

Robin Martin, Anne E. Mogg, Louise A. Heywood, Lars Nitschke, Julian F. Burke

Journal:

Molecular Genetics and Genomics

Year:

1989

Language:

english

File:

PDF, 843 KB

english, 1989

9

Design, Synthesis, and Biological Evaluation of Small, High-Affinity Siglec-7 Ligands: Toward Novel Inhibitors of Cancer Immune Evasion

Prescher, Horst, Frank, Martin, Gütgemann, Stephan, Kuhfeldt, Elena, Schweizer, Astrid, Nitschke, Lars, Watzl, Carsten, Brossmer, Reinhard

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 9.62 MB

english, 2017

10

Murine eosinophil development and allergic lung eosinophilia are largely dependent on the signaling adaptor GRB2

Willebrand, Ralf, Dietschmann, Axel, Nitschke, Lars, Krappmann, Sven, Voehringer, David

Journal:

European Journal of Immunology

Year:

2018

Language:

english

File:

PDF, 1.42 MB

english, 2018

11

Siglec-H protects from virus-triggered severe systemic autoimmunity

Schmitt, Heike, Sell, Sabrina, Koch, Julia, Seefried, Martina, Sonnewald, Sophia, Daniel, Christoph, Winkler, Thomas H., Nitschke, Lars

Journal:

Journal of Experimental Medicine

Year:

2016

Language:

english

File:

PDF, 2.87 MB

english, 2016

12

Pten controls B‐cell responsiveness and germinal center reaction by regulating the expression of IgD BCR

Setz, Corinna S, Khadour, Ahmad, Renna, Valerio, Iype, Joseena, Gentner, Eva, He, Xiaocui, Datta, Moumita, Young, Marc, Nitschke, Lars, Wienands, Jürgen, Maity, Palash C, Reth, Michael, Jumaa, Hassan

Journal:

The EMBO Journal

Year:

2019

Language:

english

File:

PDF, 4.62 MB

english, 2019

13

The role of CD22 and other inhibitory co-receptors in B-cell activation

Journal:

Current Opinion in Immunology

Year:

2005

Language:

english

File:

PDF, 1012 KB

english, 2005

14

Antibody Repertoire in a Mouse with a Simplified DH Locus: The D-Limited Mouse

GREGORY C. IPPOLITO, JUKKA PELKONEN, LARS NITSCHKE, KLAUS RAJEWSKY, HARRY W. SCHROEDER JR.

Journal:

Annals of the New York Academy of Sciences

Year:

2003

Language:

english

File:

PDF, 2.12 MB

english, 2003

15

Targeting of CD22-positive B-cell lymphoma cells by synthetic divalent sialic acid analogues

Astrid Schweizer, Miriam Wöhner, Horst Prescher, Reinhard Brossmer, Lars Nitschke

Journal:

European Journal of Immunology

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

16

TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition

Thien, Antje, Prentzell, Mirja Tamara, Holzwarth, Birgit, Kläsener, Kathrin, Kuper, Ineke, Boehlke, Christopher, Sonntag, Annika G., Ruf, Stefanie, Maerz, Lars, Nitschke, Roland, Grellscheid, Sushma-N

Journal:

Developmental Cell

Year:

2015

Language:

english

File:

PDF, 4.30 MB

english, 2015

17

Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling

Ackermann, Jochen A, Radtke, Daniel, Maurberger, Anna, Winkler, Thomas H, Nitschke, Lars

Journal:

The EMBO Journal

Year:

2011

Language:

english

File:

PDF, 1.57 MB

english, 2011

18

Immunoglobulin D-Deficient Mice can Mount Normal Immune Responses to Thymus-Independent and -Dependent Antigens

Lars Nitschke, Marie H. Kosco, Georges Kohler and Marinus C. Lamers

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.34 MB

english, 1993

19

Epratuzumab modulates B-cell signaling without affecting B-cell numbers or B-cell functions in a mouse model with humanized CD22

Özgör, Lamia, Brandl, Carolin, Shock, Anthony, Nitschke, Lars

Journal:

European Journal of Immunology

Year:

2016

Language:

english

File:

PDF, 1.33 MB

english, 2016

20

Novel human CD22 / Siglec-2 ligands with a triazole glycoside

Prescher, Horst, Schweizer, Astid, Kuhfeldt, Elena, Nitschke, Lars, Brossmer, Reinhard

Journal:

Year:

2017

Language:

english

File:

PDF, 1.58 MB

english, 2017

21

Molecular cloning, nucleotide sequence and expression inEscherichia coliof the β-cyclodextrin glycosyltransferase gene fromBacillus circulansstrain no. 8

Lars Nitschke, Karin Heeger, Hans Bender, Georg E. Schulz

Journal:

Applied Microbiology and Biotechnology

Year:

1990

Language:

english

File:

PDF, 551 KB

english, 1990

22

B cells and CD22 are dispensable for the immediate antiinflammatory activity of intravenous immunoglobulins in vivo

Schwab, Inessa, Seeling, Michaela, Biburger, Markus, Aschermann, Susanne, Nitschke, Lars, Nimmerjahn, Falk

Journal:

European Journal of Immunology

Year:

2012

Language:

english

File:

PDF, 908 KB

english, 2012

23

Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis

Jakob, Thilo, Köllisch, Gabriele V., Howaldt, Maike, Bewersdorff, Mayte, Rathkolb, Birgit, Müller, Marcel L., Sandholzer, Nadja, Nitschke, Lars, Schiemann, Matthias, Mempel, Martin, Ollert, Markus, Ne

Journal:

Journal of Allergy and Clinical Immunology

Year:

2008

Language:

english

File:

PDF, 905 KB

english, 2008

24

The role of B cell CD22 expression in Staphylococcus aureus arthritis and sepsis

Inger Gjertsson, Lars Nitschke, Andrej Tarkowski

Journal:

Microbes and Infection

Year:

2004

Language:

english

File:

PDF, 252 KB

english, 2004

25

TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition

Thien, Antje, Prentzell, Mirja Tamara, Holzwarth, Birgit, Kläsener, Kathrin, Kuper, Ineke, Boehlke, Christopher, Sonntag, Annika G., Ruf, Stefanie, Maerz, Lars, Nitschke, Roland, Grellscheid, Sushma-N

Journal:

Developmental Cell

Year:

2015

Language:

english

File:

PDF, 97 KB

english, 2015

26

BAFF , IL ‐4 and IL ‐21 separably program germinal centre‐like phenotype acquisition, BCL 6 expression, proliferation and survival of CD 40L‐activated B cells in vitro

Robinson, Marcus James, Pitt, Catherine, Brodie, Erica J, Valk, Anika M, O'Donnell, Kristy, Nitschke, Lars, Jones, Sarah, Tarlinton, David M

Journal:

Immunology & Cell Biology

Year:

2019

Language:

english

File:

PDF, 2.01 MB

english, 2019

27

B Cell-Specific Deletion of Protein-Tyrosine Phosphatase Shp1 Promotes B-1a Cell Development and Causes Systemic Autoimmunity

Lily I. Pao, Kong-Peng Lam, Joel M. Henderson, Jeffery L. Kutok, Marat Alimzhanov, Lars Nitschke, Matthew L. Thomas, Benjamin G. Neel, Klaus Rajewsky

Journal:

Year:

2007

Language:

english

File:

PDF, 2.25 MB

english, 2007

28

Molecular interactions regulate BCR signal inhibition by CD22 and CD72

Lars Nitschke, Takeshi Tsubata

Journal:

Trends in Immunology

Year:

2004

Language:

english

File:

PDF, 1.11 MB

english, 2004

29

Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells

Gruber, Sabrina, Hendrikx, Tim, Tsiantoulas, Dimitrios, Ozsvar-Kozma, Maria, Göderle, Laura, Mallat, Ziad, Witztum, Joseph L., Shiri-Sverdlov, Ronit, Nitschke, Lars, Binder, Christoph J.

Journal:

Year:

2016

Language:

english

File:

PDF, 2.46 MB

english, 2016

30

Cullin 3 Is Crucial for Pro-B Cell Proliferation, Interacts with CD22, and Controls CD22 Internalization on B Cells

Meyer, Sarah J., BÃ¶ser, Alexander, Korn, Marina A., Koller, Claudia, Bertocci, Barbara, Reimann, Lena, Warscheid, Bettina, Nitschke, Lars

Journal:

The Journal of Immunology

Year:

2020

File:

PDF, 2.55 MB

2020

31

The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils

Jiquan Q. Zhang, Björn Biedermann, Lars Nitschke, Paul R. Crocker

Journal:

European Journal of Immunology

Year:

2004

Language:

english

File:

PDF, 324 KB

english, 2004

32

Suppressing the Antibody Response with Siglec Ligands

Phimister, Elizabeth G., Nitschke, Lars

Journal:

New England Journal of Medicine

Year:

2013

Language:

english

File:

PDF, 427 KB

english, 2013

33

A multicomponent geothermometer for high-temperature basalt settings

Ystroem, Lars H., Nitschke, Fabian, Held, Sebastian, Kohl, Thomas

Journal:

Geothermal Energy

Year:

2020

File:

PDF, 3.63 MB

2020

34

Humanized CD22 transgenic mouse model for in vivo analysis of antiâCD22âbased immunotherapy

Brandl, Carolin, AngermÃ¼ller, Sieglinde, Nitschke, Lars

Journal:

European Journal of Immunology

Year:

2020

File:

PDF, 1.68 MB

2020

35

Siglec-G is a B-1 cell inhibitory receptor and also controls B cell tolerance

Journal:

Annals of the New York Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 136 KB

english, 2015

36

CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice

Tatjana Samardzic, Judith Gerlach, Kerstin Muller, Dragan Marinkovic, Jochen Hess, Lars Nitschke, Thomas Wirth

Journal:

European Journal of Immunology

Year:

2002

Language:

english

File:

PDF, 407 KB

english, 2002

37

The role of CD22 and Siglec-G in B-cell tolerance and autoimmune disease

Müller, Jennifer, Nitschke, Lars

Journal:

Nature Reviews Rheumatology (formerly Nature Clinical Practice Rheumatology)

Year:

2014

Language:

english

File:

PDF, 1.01 MB

english, 2014

38

Human CD22 cannot fully substitute murine CD22 functions in vivo, as shown in a new knockin mouse model

Wöhner, Miriam, Born, Stefanie, Nitschke, Lars

Journal:

European Journal of Immunology

Year:

2012

Language:

english

File:

PDF, 1.02 MB

english, 2012

39

Increased red cell turnover in a line of CD22-deficient mice is caused by G pi1 c : A model for hereditary haemolytic anaemia

Walker, Jennifer A., Hall, Andrew M., Kotsopoulou, Ekaterini, Espeli, Marion, Nitschke, Lars, Barker, Robert N., Lyons, Paul A., Smith, Kenneth G.C.

Journal:

European Journal of Immunology

Year:

2012

Language:

english

File:

PDF, 1.09 MB

english, 2012

40

BAFF , IL ‐4 and IL ‐21 separably program germinal centre‐like phenotype acquisition, BCL 6 expression, proliferation and survival of CD 40L‐activated B cells in vitro

Robinson, Marcus James, Pitt, Catherine, Brodie, Erica J, Valk, Anika M, O'Donnell, Kristy, Nitschke, Lars, Jones, Sarah, Tarlinton, David M

Journal:

Immunology & Cell Biology

Year:

2019

File:

PDF, 2.01 MB

2019

41

B cell defects in SLP65/BLNK-deficient mice can be partially corrected by the absence of CD22, an inhibitory coreceptor for BCR signaling

Judith Gerlach, Snigdha Ghosh, Hassan Jumaa, Michael Reth, Jürgen Wienands, Andrew C. Chan, Lars Nitschke

Journal:

European Journal of Immunology

Year:

2003

Language:

english

File:

PDF, 319 KB

english, 2003

42

CD22 is a negative regulator of B-cell receptor signalling

Lars Nitschke, Rita Carsetti, Bettina Ocker, Georges Köhler, Marinus C. Lamers

Journal:

Current Biology

Year:

1997

Language:

english

File:

PDF, 263 KB

english, 1997

43

Regulation of B Cell Functions by the Sialic Acid-Binding Receptors Siglec-G and CD22

Jellusova, Julia, Nitschke, Lars

Journal:

Frontiers in Immunology

Year:

2012

Language:

english

File:

PDF, 1.24 MB

english, 2012

44

B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24)

Roland H. Wenger, Manfred Kopf, Lars Nitschke, Marinus C. Lamers, Georges Köhler, Peter J. Nielsen

Journal:

Transgenic Research

Year:

1995

Language:

english

File:

PDF, 1.04 MB

english, 1995

45

10.1038/88756

Tedford, Kerry, Nitschke, Lars, Girkontaite, Irute, Charlesworth, Amanda, Chan, Gordon, Sakk, Vadim, Barbacid, Mariano, Fischer, Klaus-Dieter

Journal:

Nature Immunology

Year:

2001

Language:

english

File:

PDF, 1.05 MB

english, 2001

46

Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy

Sivertsen Åsrud, Kathrine, Pedersen, Line, Aesoy, Reidun, Muwonge, Haruna, Aasebø, Elise, Nitschke Pettersen, Ina Katrine, Herfindal, Lars, Dobie, Ross, Jenkins, Stephen, Berge, Rolf Kristian, Henders

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 7.38 MB

english, 2019

47

Reduction of marginal zone B cells in CD22-deficient mice

Tatjana Samardzic, Dragan Marinkovic, Claus-Peter Danzer, Judith Gerlach, Lars Nitschke, Thomas Wirth

Journal:

European Journal of Immunology

Year:

2002

Language:

english

File:

PDF, 249 KB

english, 2002

48

CD22 and Siglec-G: B-cell inhibitory receptors with distinct functions

Journal:

Immunological Reviews

Year:

2009

Language:

english

File:

PDF, 450 KB

english, 2009

49

Siglec-G is a B1 cell–inhibitory receptor that controls expansion and calcium signaling of the B1 cell population

Hoffmann, Anja, Kerr, Sheena, Jellusova, Julia, Zhang, Jiquan, Weisel, Florian, Wellmann, Ute, Winkler, Thomas H, Kneitz, Burkhard, Crocker, Paul R, Nitschke, Lars

Journal:

Nature Immunology

Year:

2007

Language:

english

File:

PDF, 675 KB

english, 2007

50

Identification of Distinct Unmutated Chronic Lymphocytic Leukemia Subsets in Mice Based on Their T Cell Dependency

Pal Singh, Simar, de Bruijn, Marjolein J. W., de Almeida, Mariana P., Meijers, Ruud W. J., Nitschke, Lars, Langerak, Anton W., Pillai, Saravanan Y., Stadhouders, Ralph, Hendriks, Rudi W.

Journal:

Frontiers in Immunology

Year:

2018

Language:

english

File:

PDF, 2.23 MB

english, 2018

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